We call these cofactors, and they are believed not only to be critical to bone health but also to be most effective when present together in adequate amounts. 3Ĭalcium’s effects, however, depend heavily on the actions of several other vitamins and minerals, including vitamin D, magnesium, vitamin K2, and zinc. Calcium is well-known for its benefits to bone mineral density, as it is the most abundant mineral in the human body. 2 Consuming the necessary vitamins and minerals from food as well as from dietary supplements should be an important pillar of any bone-health program. This includes exercise and also diet, with evidence indicating that nutrition plays a major role in promoting skeletal health. 1Ĭombating osteoporosis is a lifelong endeavor requiring prudent lifestyle choices. Estimates suggest that by 2025, osteoporosis will be the source of three million fractures and over $25 billion in healthcare costs each year. Osteoporosis significantly increases risk of fracture, with studies suggesting that one in two women and one in four men over the age of 50 will experience a broken bone as a result. We invite you to explore this comprehensive scientific overview identifying vitamin K2’s essential role as a companion nutrient to vitamin D, including new safety evidence stressing the importance of co-supplementation.Loss of bone density impacts 54 million Americans, putting them directly in the path of danger of developing osteoporosis. Yet the work continues, with new clinical trials evaluating the efficacy of these vitamins’ combination in different health areas such as metabolic dysfunction, fracture healing, respiratory infection, and more. From there, interventional studies have proven that combining vitamins K2 and D3 positively impacted bone mineral density in both children and adults, and clinical research have demonstrated their beneficial influence on cardiovascular and insulin metabolism markers in adults. Observational studies have demonstrated a correlation between low K and D status with compromised bone health and increased cardiovascular risks.

Just as vitamins K2 and D3 are fat-soluble vitamins that function synergistically, the deficiency of both these nutrients has been recognized worldwide and is associated with various health issues.

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